Health Effects: Methyl Methacrylate may damage the nervous system causing numbness, "pins and needles," and/or weakness in the hands and feet. * Methyl Methacrylatemay affect the liver and kidneys. Methyl methacrylate | C5H8O2 | CID 6658 - structure, chemical names, physical and chemical properties, classification, patents, literature, biological activities . Some types of phthalates have affected the reproductive system of laboratory animals. Halliwell B (1994). is a natural antibacterial agent that is produced by Lactococcus lactis and has been approved by the . Skin, eye and mucous membrane irritation. 8 The reported half-life of this process is 15 hours (hydroxyl) and 1 day (ozone), respectively. Health and environmental effects profile for Methyl Methacrylate. The U.S. Department of Energy's Office of Scientific and Technical Information . However, the International Agency for Research on Cancer (IARC) said it was . Collapse. Poly(methyl methacrylate) sc-255435 Hazard Alert Code Key: EXTREME HIGH MODERATE LOW RISK EMERGENCY OVERVIEW May cause SENSITIZATION by inhalation and skin contact. Methyl methacrylate (MMA) is an organic compound with the formula CH 2 =C(CH 3)COOCH 3. . 224 Acta Chim. Methyl methacrylate (MMA), a monomer of acrylic resin, has a wide variety of dental, medical and industrial applications. Occ. MMA can affect the nervous system, causing symptoms similar to drunkenness, but most people will experience irritation first. These are used in construction, automotive, consumer products and in making signs. A locked padlock) or https:// means you've safely connected to the .gov website. using the same exposure, protocol assessed the effects of methyl methacrylate on terminal body weight, tissue weights (adrenals, epldldymal and popliteal fat pads), blood chemistry and metabolic parameters. women who often change their fingernails and are daily exposed to methyl methacrylate. Methyl methacrylate-potassium acrylate copolymer | C8H11KO4 | CID 23693564 - structure, chemical names, physical and chemical properties, classification, patents, literature, biological activities, safety/hazards/toxicity information, supplier lists, and more. It does list concerns that it can be a carcinogen, cause allergic reactions, immunotoxicity, and organ system toxicity. Prepared by the Office of Health and Environmental Assessment, Environmental Criteria and Assessment . Methyl methacrylate (MMA) is a monomer, commonly used in neurosurgery, orthopedic surgery, and in dental clinics. 1, 11-15, 2008. OSHA PEL: TWA 100 ppm (410 mg/m3) NIOSH REL: TWA 100 ppm (410 mg/m3) Health effects. Overview Health effects Environmental effects Sources of emissions References Description The primary use of methyl methacrylate is the production of acrylic plastics and resins (trade names are Lucite, Plexiglas and Perspex) for sheeting and molding compounds. Identified uses : Methyl methacrylate is used in the manufacture of methacrylate resins and plastics (e.g., Plexiglas). The Health and Environmental Effects Profile for methyl methacrylate was prepared by the Office of Health and Environmental Assessment, Environmental Criteria and Assessment Office, Cincinnati, OH for the Office of Solid Waste and Emergency Response to support listings of hazardous constituents of a wide range of waste streams under Section 3001 of the Resource Conservation and Recovery Act . Volatilization of methyl methacrylate from moist soil surfaces is expected to be an important fate process (SRC) given an estimated Henry's Law constant of 3.2X10-4 atm-cu m/mole (SRC), based upon its vapor pressure, 38.5 mm Hg (4), and water solubility, 1.57X10+4 mg/L (5). Structure of methyl methacrylate. The correct terminology is Methyl Methacrylate - MMA for short. Chemistry Dashboard. Available online: https://pubmed.ncbi.nlm.nih.gov/19534085/ Fakhouri J, Sarkis R, Chababi-Atallah M, Aftimos G. Toxic effects of methyl methacrylate monomer on male genital tissues. Scientific PapersToxicity of methyl methacrylate in dentistry. However the use of MMA has been associated with adverse health effects, and MMA-based acrylic nails will be tough, inflexible and difficult to remove. Health and environmental effects profile for Methyl Methacrylate. Summary of HEAST Information on-Line: Subchronic and Chronic Toxicity: Chronic [RfD]: IRIS: Subchronic [RfD]: on-Line : Chronic [RfC]: . High exposure can cause dizziness, irritability, difficulty with concentration and . The synonyms for MMA listed in MEDLARS (1986), are as follows: metakrylan metylu; methacrylate de methyle; methacrylic acid methyl ester (8CI); methacrylsaeuremethyl ester; Figure 1. Used to manufacture plastics, construction chemicals, and textile applications; Exposure Limits. Methyl methacrylate CASRN 80-62-6 | DTXSID2020844. Share sensitive information only on official, secure websites. California Occupational Safety & Health Standards Board: Initial and Final Statement of Reasons. *Methyl Methacrylatemay cause a skin allergy. Monitoring by means of blood and urine analysis for methanol was successfully applied in 32 male workers who were exposed to methyl methacrylate (MMA) monomer at 6 ppm as a geometric mean and at 112 ppm as the maximum. When exposed to MMA in the work environment, surgical staff have been reported to suffer from hypersensitivity, asthmatic reactions, local neurological symptoms, irritations and local dermatological reactions. (2) Uses Methyl methacrylate is used in the manufacture of methacrylate resins and plastics (e.g., Plexiglas). Scientific PapersToxicity of methyl methacrylate in dentistry. Cross-sectional study of health effects of methyl methacrylate monomer among dental laboratory technicians. Evaluation of the Chronic Toxicity and Carcinogenicity of Methyl Methacrylate (80-62-6) in Male B6C3F1 Mice via Whole Body Respiratory Exposure. (,,,11) The principal uses of methyl methacrylate are: cast sheet and other grades (advertising signs and displays, lighting fixtures, glazing and skylights, building panels and sidings, and plumbing and bathroom fixtures), molding/extrusion powder, and coatings (latex paints . The more often you use these products, the greater the risk will be. Health Effects Laboratory Division, Allergy and Clinical Immunology Branch, National Institute for Occupational Safety and Health (NIOSH), Morgantown, WV 26505, USA . Poly(methyl methacrylate) (PMMA) belongs to a group of materials called engineering plastics.It is a transparent thermoplastic.PMMA is also known as acrylic, acrylic glass, as well as by the trade names and brands Crylux, Plexiglas, Acrylite, Astariglas, Lucite, Perclax, and Perspex, among several others ().This plastic is often used in sheet form as a lightweight or shatter-resistant . Canada (1993) review to assess the potential effects on human health of indirect exposure to methyl methac-.. View Record in Scopus Google Scholar . If allergy develops, very low future exposure can cause itching and a skin rash. Yuji Nishiwaki, Takehito Saitoh, Toru Takebayashi, Shigeru Tanaka, Norihito Etoh, Yoko Eitaki, . Methyl methacrylate is used in the manufacture of resins and plastics. An experimental study. 56, no. 2PROPENOIC ACID, 2METHYL, METHYL ESTER and METHYL METHACRYLATE. using the same exposure, protocol assessed the effects of methyl methacrylate on terminal body weight, tissue weights (adrenals, epldldymal and popliteal fat pads), blood chemistry and metabolic parameters. Enter the email address you signed up with and we'll email you a reset link. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.) Cancer . MMA can cause allergic skin reactions, according to the Occupational Safety and Health Administration 1. Ingredients linked to developmental and reproductive toxicity, a broad class of health effects that range from infertility and reproductive organ cancers to birth defects . The empirical formula for MMA is C 5H 8O 2, and the CAS registry number is 80-62-6. Respiratory Tightness in chest, wheezing, cough, occupational asthma (due to particles in air) and shortness of breath. Repeated exposure to high levels produces adverse effects on the heart, lungs, liver and kidneys. Methacrylates are generally of low toxicity, have not been found to damage reproduction or harm the unborn child, and studies in workers exposed to methacrylates for more than 30 years indicate that there is no increased risk of developing cancer due to occupational exposure. Objectives: This is because of the lack of corroborating animal or . Experimental and clinical studies have documented that monomers may cause a wide range of adverse health effects such as irritation to skin, eyes, and mucous membranes, allergic dermatitis, stomatitis, asthma, neuropathy, disturbances of the central nervous system, liver toxicity, and fertility disturbances. See annual publication for most recent information. Based on the results of the health effects research presented in this report, and the ambient concentration estimates, it appears that methyl methacrylate as an air pollutant does not pose a threat to the health of the general population. The integrity of latex gloves may also be compromised following exposure to MMA during surgical procedures. The MMA monomer is a colorless, pungent liquid metabolized to methacrylic acid, with described toxicities to various tissues [ 3, 4 ]. Summary of HEAST Information on-Line: Subchronic and Chronic Toxicity: Chronic [RfD]: IRIS: Subchronic [RfD]: on-Line : Chronic [RfC]: . Int ity, cause, or consequence . Arch. Experimental and clinical studies have documented that monomers may cause a wide range of adverse health effects such as irritation to skin, eyes, and mucous membranes, allergic dermatitis, stomatitis, asthma, neuropathy, disturbances of the central nervous system, liver toxicity, and fertility disturbances. What are the health risks? Methacrylate (7) and Health and Environmental Effects Profile for Methyl Methacrylate. It is present in nail preparations used in and beauty salons throughout Australia. A product such as hairspray that contains MMA can also cause itching, redness and tearing of the eyes. Previous studies have highlighted the adverse effects and toxicity of PMMA (poly (methyl methacrylate))-based dental materials, at both the tissue and cellular levels, although systemic toxicity . The objective is to develop smart polymer nanocomposites using spray-coated graphene nanoplatelet (GNP)-doped polymethyl methacrylate on the surface of aluminium beams (2024-T351) and monitor gauge . Free radicals, antioxidants, and human disease; curios- health effects in workers occupationall y exposed to methylmethacrylate . 227-232. It has a relatively high vapour pressure (4000 Pa at 20C ), moderate water solubility (15 800 mg/L), and a low log octanol:water partition coefficient (K ow ) (1.38) (ACGIH, 1986; Dean, 1985; Tanii and Hashimoto, 1982).